The effects of inorganic phosphate and creatine phosphate on force production in skinned muscles from rat ventricle.
نویسندگان
چکیده
منابع مشابه
Inorganic phosphate speeds loaded shortening in rat skinned cardiac myocytes.
Force generation in striated muscle is coupled with inorganic phosphate (P(i)) release from myosin, because force falls with increasing P(i) concentration ([P(i)]). However, it is unclear which steps in the cross-bridge cycle limit loaded shortening and power output. We examined the role of P(i) in determining force, unloaded and loaded shortening, power output, and rate of force development in...
متن کاملEffects of calcium, inorganic phosphate, and pH on isometric force in single skinned cardiomyocytes from donor and failing human hearts.
BACKGROUND During ischemia, the intracellular calcium and inorganic phosphate (P(i)) concentrations rise and pH falls. We investigated the effects of these changes on force development in donor and failing human hearts to determine if altered contractile protein composition during heart failure changes the myocardial response to Ca(2+), P(i), and pH. METHODS AND RESULTS Isometric force was st...
متن کاملEffects of Calcium, Inorganic Phosphate, and pH on Isometric Force in Single Skinned Cardiomyocytes From Donor and Failing Human Hearts
Background—During ischemia, the intracellular calcium and inorganic phosphate (Pi) concentrations rise and pH falls. We investigated the effects of these changes on force development in donor and failing human hearts to determine if altered contractile protein composition during heart failure changes the myocardial response to Ca, Pi, and pH. Methods and Results—Isometric force was studied in m...
متن کاملIntracellular pH and Inorganic Phosphate Effects on Skeletal Muscle Force
121 used as stubstituents on Ci and C2; namely H, CH 3 , C 2 H 5 , and CeHs. They are differentiated to have approximately 1, 2, 3, and 5 A in their diameters as spherical models. For simplified discussion, we consider that 2 has bulkier substituents on Ci than on C2. Thus the C2 site will be more reactive than the Ci site for dimerization. In this occasion discussion will be rather limited to ...
متن کاملstudy the effects of low level laser diode on no production and healing of diabetic and cortisone acetate and normal wounded sd rats
nitric oxide (no) is a small molecule synthesized by most of mammalian cells with diverse biological activities including vasodilatation, host defense and wound healing. impaired wound healing is a common occurrence among diabetics and patients receiving glucocorticoid therapy. on the other hand the application of laser in biomedical area have been increased. thus, the current studies were desi...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1986
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1986.sp015952